This hit overlaps NEGR1 (top SNP rs1194283, odds ratio (OR) = 1.05, SE = 0.0065, P = 6.71 × 10−13; Fig. 3g), which has been identified as an MDD risk locus in multiple GWASs with varying phenotyping approaches4,6,8,35–37. Here, NEGR1 is linked to major depressive disorder.