High-risk prognostic genes BMP4, CELSR3, GPRC5C, and RUNDC3B, highly expressed in Epithelial Cells, CCBE1 showed expression in Leydig cells, SCGB2A2 highly expressed in Epithelial Cells and Cancer cells, suggesting that Epithelial cell play an important role in tumor growth and initiation. This evidence concerns the gene CELSR3 and cancer.