Finally, in screening for small molecule compounds that upregulate UGT2B11 mRNA, obeticholic acid, the natural FXR agonist also known as INT-747 or 6α-ethyl-chenodeoxycholic acid inhibits Hepatocellular carcinoma proliferation, migration, and invasion via interfering with the activation of IL-6/STAT3 signaling pathway47. This evidence concerns the gene NR1H4 and hepatocellular carcinoma.