It was discovered that to the TNBC stemness index, five genes related, including RUNDC3B, PROS1, PCDHGA3, CCBE1, and GPRC5C, were downregulated in cancer tissue compared to normal Breast tissue, and GLDC, CXCL11, and CELSR3 were up-regulated in breast cancer tissue compared to normal tissue as shown in (Supplementary Fig. 6). The gene discussed is CELSR3; the disease is cancer.