GSDMD and infection: Table S2 shows a strong Spearman’s rank correlation for ICU admittance (r:0.55), airway inflammation (r:0.45), macrophage predominant inflammation (r:0.49), hemorrhage (r:0.41), type II pneumocyte hyperplasia (r:0.45), and hyaline membranes (r:0.58) with cleaved gasdermin D, suggesting a significant role in clinical disease severity, lung pathology, and infection outcome.