Furthermore, the expression of a set of additional anti-oxidant genes (Gpx4, Prdx3, Sod2, and Gsta4) were significantly reduced in the HF-Pr2 group compared with the HF group (Figure 2c), clearly indicating a protective effect of the probiotic mix on oxidative and ER stresses in the liver of mice fed a HF diet. This evidence concerns the gene GSTA4 and hydrops fetalis.