Single cells (SC) were isolated from a portion of paired fresh tumor, peritumor and peripheral blood from 7 donors with pathologically confirmed PLC (P121-P123 ICC, P124-P125 HCC, P126-P127 CHC), meanwhile a portion of metastatic lymph node was collected from P126. This evidence concerns the gene HSPG2 and intrahepatic cholangiocarcinoma.