HMGB3 and neoplasm: Further, we employed SCENIC to predict transcription patterns of tumor cells, finding a series of key TFs of HCC tumorigenesis, such as TFs in regulation of cell dedifferentiation (SPI1, HMGB3, and YBX1) and in abnormal bile acid metabolism (NR1H4, NR1I3, FOXA3 and DDIT3).