JAK1 and intrahepatic cholangiocarcinoma: For instance, bulk-detected KRAS (T121), JAK1 (T122), and IDH1 (T123) were found in corresponding ICC-specific sub-clusters (C2, C6 and C16), and tumor suppressor genes such as ARID1A (T124) and SMARCA4 (N126) were found transcriptionally inactive in corresponding sub-clusters41–43 (Supplementary Fig. 3e).