Gal-4 was significantly associated with IHD (n = 126, 40.8%) and severity of HF symptoms (NYHA-class III-IV, n = 263, 85.1%) in unadjusted and Model 1 adjusted analyses, but the association was attenuated upon Model 2a adjustment (Supplementary Tables S3, S4). The gene discussed is LGALS4; the disease is hydrops fetalis.