TNF and cancer: Given our transcriptomics analysis, which indicated elevated expression of inflammation-related genes and downregulation of the Wnt/β-catenin pathway in BrafV637E-expressing cells, we tested the effect of anti-inflammatory drugs, specifically dexamethasone and CC-5013 (Lenalidomide; TNF-alpha inhibitor) as well as CHIR- 99021 (Wnt/β-catenin activator) on our cancer organoids.