For investigation, both Asian groups seemed to be more susceptible to diseases Platelet glycoprotein IV deficiency, Lissencephaly 5, Deafness, autosomal recessive 111, Dyssegmental dysplasia, Silverman-Handmaker type/Schwartz-Jampel syndrome, type 1 and Citrullinemia, adult-onset type II / Citrullinemia, type II, neonatal-onset which were caused by mutations in CD36, LAMB1, MPZL2, HSPG2 and SLC25A13 supported by a slightly higher GCR compared to other ethnic groups12,15, restating the importance of strategic and peculiar drug development to target affected population (Supplementary Fig. 12). This evidence concerns the gene LAMB1 and cobblestone lissencephaly without muscular or ocular involvement.