For investigation, both Asian groups seemed to be more susceptible to diseases Platelet glycoprotein IV deficiency, Lissencephaly 5, Deafness, autosomal recessive 111, Dyssegmental dysplasia, Silverman-Handmaker type/Schwartz-Jampel syndrome, type 1 and Citrullinemia, adult-onset type II / Citrullinemia, type II, neonatal-onset which were caused by mutations in CD36, LAMB1, MPZL2, HSPG2 and SLC25A13 supported by a slightly higher GCR compared to other ethnic groups12,15, restating the importance of strategic and peculiar drug development to target affected population (Supplementary Fig. 12). The gene discussed is HSPG2; the disease is citrullinemia.