For example, genes UGT1A1, SERPINB7 and ABCG5 were responsible for Crigler-Najjar syndrome, palmoplantar keratosis, phytosterolaemia, exhibited significantly lower GCR in non-Asian ethics compared to that of the Asian ethnic group, suggesting heterogeneous GCR at the population level needed to consider a population-centric priority for the variable genes when implementing preventative strategies or diagnostic strategies6,12,24. The gene discussed is UGT1A1; the disease is palmoplantar keratosis.