PLCG2 and graft versus host disease: The enrichment analysis revealed that the pathways involved in graft-versus-host disease, antigen processing and presentation (e.g., CD74 and TAPBP), leukocyte trans-endothelial migration and cell adhesion (e.g., ITGB2, ITGB7, ITGAL, CD2 and CD226) and NK-mediated cytotoxicity (e.g., GZMB, PRF1, KLRD1, ITGAL, ITGB2 and PLCG2) were most altered among the upregulated genes in CD8 TEMRA of iPD vs HC (Fig. 6j–m).