GBA1 and Parkinson disease: In the discovery analysis, we systematically scrutinized various immune subsets and their functional states in 28 PD patients (25 iPD aged 60-70 years and three genetic PD patients with mutations in GBA or PINK1) and 24 matched healthy controls (HC) (refer to “cohort design” in “Methods”, Supplementary Tables 1 and 2; for simplicity, ‘PD patients’ are hereafter shortened as PD).