Our unbiased volcano plot analysis (Fig. 1c) showed that the frequency of cytotoxic terminally-differentiated effector memory T cells (CD45RA+CCR7−, TEMRA)24,25 was substantially increased among total CD8 T cells (Fig. 1c, e), whereas the frequency of CD8 TCM was reduced in PD (Fig. 1f). The gene discussed is CD8A; the disease is Parkinson disease.