Previous studies found that ESRP2 controls a conserved epithelial splicing program specifically involved in epithelial‐mesenchymal transition (EMT)‐associated alternative splicing, such as promoting splicing of the epithelial variants of the FGFR2, CTNND1, CD44, and ENAH transcripts.[7, 8] In addition, ESRP2 has been reported to regulate splicing events of Hippo signaling in hepatocytes and participate in regulating postnatal hepatocytes differentiation,[9] liver regeneration,[10] severe alcoholic hepatitis,[11] and hepatobiliary carcinogenesis in non‐alcoholic fatty liver disease. This evidence concerns the gene ESRP2 and alcoholic hepatitis.