HMGB1 and hepatocellular carcinoma: [40] Here, we demonstrate that TAK1 inhibition in HCC cells leads to GSDME‐mediated pyroptotic cell death and the release of HMGB1, which promotes T cell infiltration, potentially turning “cold tumors” into “hot tumors.” Although our data clearly showed that TAK1 inhibition leads to pyroptosis, other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, cannot be excluded.