YAP1 and hepatocellular carcinoma: [35] It is noteworthy that ESRP2 has been reported to control the splicing of Hippo components, such as facilitating the expression of adult NF2, HK, YAP1, and TEAD1 isoforms, leading to the dysregulation of Hippo signaling in various diseases.[9, 10, 11, 12] Here, we demonstrated a global map of ESRP2‐affected RNA splicing alterations in HCC, in which multiple splice isoforms undergo a fetal‐to‐adult transition.