Our findings indicated that Ang II administration induced cardiac hypertrophy and dysfunction, as evidenced by elevated IVSD, LVPWD, RWT, HW, LVW values, as well as HW/TL and LVW/TL ratios (Figure 1A–C) and Figure S1A–D), along with decreased EDV, ESV, LVEF, LVFS, and LVDD, LVDS (Figure 1E–H), Figure S1E,F and Table 1). The gene discussed is AGT; the disease is cardiac hypertrophy.