AGER and Insulin resistance: Dysregulated RAGE and TLR signaling are suspected to perturb the inflammatory environment classically seen in those with insulin resistance, thereby contributing to the development and progression of insulin resistance (Cassese et al., 2008; Creely et al., 2007; Giacco & Brownlee, 2010; Jialal et al., 2014; Schmidt et al., 2001).