Furthermore, combined metformin with empagliflozin significantly enhanced the inhibitory effect of the respective empagliflozin alone on the insulin, glucose levels, and HOMA‐IR in PCOS‐IR rats (fasting insulin, 10.33 ± 1.16; glucose, 5.93 ± 0.88; HOMA‐IR, 2.69 ± 0.51; p < 0.05). Here, INS is linked to polycystic ovary syndrome.