This causes a reduction in SHBG, an increase in ovarian androgen production, and a decrease in follicular maturation; the PCOS‐IR progresses, and eventually can lead to long‐term complications such as diabetes, fatty liver, hypertension, metabolic syndrome, ischemic heart disease, and uterine cancer (Li et al., 2019). Here, SHBG is linked to polycystic ovary syndrome.