Furthermore, use of metformin or empagliflozin showed significant improvement in estradiol level (PCOS‐IR Met, 110.56 ± 3.05; PCOS‐IR Empa, 109.96 ± 3.62; vs. PCOS‐IR 63.1 ± 6.82 p < 0.05), LH levels (PCOS‐IR Met, 22.14 ± 2.23; PCOS‐IR Empa, 22.56 ± 2.33; vs. PCOS‐IR 53.54 ± 7.81 p < 0.05), and FSH levels (PCOS‐IR Met, 2.1 ± 0.23; PCOS‐IR Empa, 2 ± 0.31; vs. PCOS‐IR 5.54 ± 0.83 p < 0.05). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.