SIRT1 and polycystic ovary syndrome: Also, there was a significant decrease in the relative expression of SIRT1 in ovarian tissue in PCOS‐IR rats than that in the control rats (0.31 ± 0.07 ± 5.63 vs. 11.02 ± 0.01; p < 0.05) (Figure 2).We reported significant improvement in the relative expression of SIRT1 levels with use of metformin, empagliflozin, and their combination (PCOS‐IR Met, 0.73 ± 0.05; PCOS‐IR Empa, 0.73 ± 0.05; PCOS‐IR Met+Empa, 0.89 ± 0.06 vs. PCOS‐IR 0.38 ± 0.12 ± 31.5 p < 0.05).