INS and Hyperglycemia: Metformin can also indirectly inhibit chronic inflammation through enhancing insulin sensitivity, regulating hyperglycemia, preventing formation of advanced glycation end‐products (AGEs), and diabetic atherogenic dyslipidemia (Kuryłowicz & Koźniewski, 2020; Nasri & Rafieian‐Kopaei, 2014; Zhou et al., 2018).