Because we found that up to 30% of the HAP1 cell clones showed a deletion of the PAPSS2-PTEN locus without stressors applied (Fig 5B) and considering that HAP1 cells originated from chronic myelogenous leukemia, we further investigated the occurrence of this deletion across cancer types using patient data. Here, PAPSS2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.