AKT1 and breast cancer: Calcium channels have also been shown to promote cancer cell migration and invasion, through the regulation of cytoskeletal dynamics.[52] For example, VGCCs were reported to promote cell migration and invasion in glioma cells through the activation of the RhoA/ROCK pathway.[53] Similarly, TRP channels were shown to promote cell migration and invasion in breast cancer cells through the activation of the PI3K/Akt pathway.[54] (iii) Tumor angiogenesis.