MT-ND5 and inborn mitochondrial metabolism disorder: reported that their enhanced mitochondrial DNA editing tool (DdCBE‐NES + mitoTALEN) was successfully used to generate a mouse model with the m.G12918A mutation in the ND5 gene associated with mitochondrial genetic disorders in humans.[44] Consistent with the study of Lee et al., we micro‐injected DddA11‐T1391A‐xAID‐NES2 mRNA targeting ND5 (m.G12918) into one‐cell stage mouse embryos and measured mtDNA editing frequencies in blastocysts via targeted deep sequencing.