Recently, a large number of studies have been reported that nanotechnology‐based pyroptosis can induce antitumor immune response.[3, 79, 87] For example, Lin et al. developed biodegradable upconversion nanoparticles K3ZrF7:Yb/Er (denoted as ZrNPs) which could be dissolved inside cancer cells and release a large amount of ions like K+ and [ZrF7]3− for a high intracellular osmolarity and impaired homeostasis imbalance (Figure 6).[70] This process caused ROS increment, caspase‐1 activation, GSDMD cleavage and IL‐1β release. This evidence concerns the gene GSDMD and cancer.