Kwon et al. confirmed that HO‐1 was able to induce LPO for tumor ferroptosis.[61] Although DOX is generally used in chemotherapy, it can also induce ferroptosis via heme synthesis obstruction leading to iron overload cascade with ferroptosis in mitochondria.[62] Doll et al. showed that ferroptosis suppressor protein 1 (FSP1) catalyzed the regeneration of coenzyme Q10 (CoQ10) through NAD(P)H, and then combined with GPX4 and GSH to inhibit phospholipid peroxidation.[63] Thus, it can increase ferroptosis sensitivity when losing FSP1 ubiquitin by CoQ10 decrement and LPO generation. This evidence concerns the gene AIFM2 and neoplasm.