Sun et al. constructed a prodrug nanomicelle (AOZN) self‐assembly from γ‐oryzanol (Orz) as a DNA methyltransferases inhibitor and α, β‐methylene adenosine 5′ diphosphate (AMPCP) as an adenosine inhibitor connected with a GSH‐responsive crosslinker (Figure 6).[77] The released Orz upregulated GSDMD expression and AMPCP facilitated caspase‐1 activation with ATP level increment, both of which induced tumor pyroptosis. This evidence concerns the gene GSDMD and neoplasm.