HMOX1 and neoplasm: In addition, ferroptosis that occurs directly in Tregs can also promote tumor immunotherapy.[29] Similarly, MDSC with immunosuppressive functions demonstrates resistance to ferroptosis driven by N‐acylsphingosine aminohydrolase 2 (ASAH2) mediated p53‐heme oxygenase‐1 (HMOX1) axis.