found that ferroptosis was suppressed in ALOX12 knockout U2OS cells and that loss of one ALOX12 allele was sufficient to abolish p53‐mediated ferroptosis and accelerate tumorigenesis, indicating that the ferroptosis pathway mediated by ALOX12 was critical for p53‐dependent tumor suppression.[59] Voltage dependent anion channels (VDACs) are transmembrane channels that transport ions and metabolites, and play an important role in the process of iron degradation. Here, TP53 is linked to neoplasm.