Zhang et al. developed a novel multifunctional nano PROTAC (named as CREATE) to precisely degrade BRD4.[142] Specifically, the authors used a pH/GSH responsive polymer (disulfide linked poly (lactic‐co‐glycolic acid), referred to DS‐PLGA) to load dBET6 self‐assembly into nanoparticles, which was coated by an engineered lung cancer cell membrane (CRV‐LLCM) with dual targeting ability to form a biomimetic nanosystem (Figure 11). Here, BRD4 is linked to lung carcinoma.