Mao et al. found that platinum (II) complexes could serve as photoactivators for the cGAS‐STING pathway activation with mitochondrial/nuclear DNA damage, accompanied by pyroptosis with potent antitumor immune activity.[89] Thus, a variety of nanoplatforms can be applied into pyroptosis immunity via osmolarity elevation, ROS generation as well as glycometabolism with GSDMD cleavage during cancer treatment. Here, GSDMD is linked to cancer.