The pores serve as channels for IL‐1β and IL‐18 release, which ultimately lead to cell death.[85] Ning et al. found that the loss of mixed‐lineage leukemia 4 (MLL4) weakened the strength of classical and super enhancers, thereby weakening the expression of Argonaute 2 (AGO2) and DNA methyltransferase 1 (DNMT1) in the RNA‐induced silencing complex (RISC).[86] This process promoted double‐stranded DNA stress, induced GSDMD expression and N‐terminal hydrolysis, and initiated tumor cell pyroptosis. This evidence concerns the gene GSDMD and neoplasm.