Specifically, we used high‐confidence modifiers identified in Drosophila disease models as inputs for MLnet: 113 modifiers for AD, 209 modifiers for HD, 36 modifiers for SCA1, and 59 modifiers for SCA3 (see Methods and Protocols for details and Dataset EV1 for the list of modifiers). Here, ATXN3 is linked to Alzheimer disease.