To test for this possibility, we predicted common modifiers for pairs of diseases such as AD and HD (a), and SCA1 and SCA3 (b) – or other pairings – using MLnet and then used the predicted common modifiers from (a) and (b) as seeds in the final MLnet prediction of common modifiers (c) (Appendix Fig S3A). The gene discussed is ATXN3; the disease is Alzheimer disease.