Collectively, the reducing effects of HMBA on body weight and food intake were completely abrogated by silencing of Myh9 and Actg1 in AgRP (Fig 5L and M) and POMC (Fig 5N and O) neurons, suggesting that MYH9 and ACTG1 are required for the anti‐obesity effects of HMBA. Here, AGRP is linked to obesity due to melanocortin 4 receptor deficiency.