Although PBXIP1 has been reported to be related to diverse biological processes such as hematopoiesis, estrogen signaling‐related cellular function, reproduction biology, and cancers (Khumukcham & Manavathi, 2021) since its discovery in 2000 (Abramovich et al., 2000), the role of PBXIP1 on AD is rarely studied. This evidence concerns the gene PBXIP1 and Alzheimer disease.