In addition to the transcriptional regulation of Nrf1 and Nrf2, it has been observed in thyroid carcinoma (PTC) tissues that demethylases, such as the demethylase fat mass and obesity-associated protein (FTO), can promote ferroptosis by down-regulating m6A methylation of SLC7A11 [14]. The gene discussed is MBD2; the disease is thyroid gland carcinoma.