Mechanistically, G protein‐coupled receptor 137 (GPR137) was identified as a newly splicing target of ESRP1, and a low level of ESRP1 as well as an elevated level of the long version of GPR137 could differently mediate the Wnt/β‐catenin signalling pathway, thus impairing intestinal barrier integrity and increasing the susceptibility to colitis or CAC (Figure 3D).51 The gene discussed is GPR137; the disease is colitis.