PTPRS and inflammatory bowel disease: In human IBD, three SNPs (rs17130, rs886936 and rs8100586) that flanked exon 8 in the PTPRS gene were found to result in potential alternate splicing of exon 9 and meB, which could entirely remove the third immunoglobulin like domain of PTPσ and alter the ligand binding or recognition for E‐cadherin and β‐catenin.