The results showed that the luciferase activity of the reporters containing mutant sequences were similar between the IGF2BP2 knockdown group and control group (Figure 6E,F). MeRIP assay and qRT‐PCR verified that the key recognition sequences of the A and B sequences screened in the above experiments had indeed m6A modifications (Figure 6G,H). In addition, three biotinylated RNA probes were designed (Figure S4C, Supporting Information) based on the sequences of A and B, and RNA‐pulldown assays was performed in MDA‐MB‐231 and HCC‐1806 wild type cells. The gene discussed is IGF2BP2; the disease is hepatocellular carcinoma.