Recently, the pathological effects of extrahepatic local SAA have been gaining wider attention, such as in experimental autoimmune encephalomyelitis and cancer.[12, 13] Thus far, studies focused on the SAA regulation in the liver or small intestine.[14] However, the regulation of colonic SAA in colitis remains largely unexplored. The gene discussed is SAA2; the disease is experimental autoimmune encephalomyelitis.