TF and infection: When both cell types were compared directly (at 15 min; Fig 1C), we observed a reduction in Tf recycling levels caused by infection (% mean Tf recycling ± SEM: WT Mock– 100.0 ± 0.0% versus WT PR8–47.7 ± 5.1%, DN Mock– 87.2 ± 2.3% versus DN PR8–27.1 ± 4.5%).