Interestingly, in an experimental autoimmune encephalomyelitis (EAE) model, the frequency of Igha+ B cells found in the homeostatic dura mater decreased significantly followed by a significant expansion of Ighm and Ighg expression in B cells during inflammation [93], in a process similar to the results presented in this study. This evidence concerns the gene IGHM and experimental autoimmune encephalomyelitis.