It is important to note that the majority of the cells within the B cell compartment were assigned as IgM+ and IgG+ plasma cells as shown before [2,42,46,93,94], although their composition (IgA+ versus IgM+ and/or IgG+) differs slightly from previous elegant work describing the diversity of meningeal B cells compartment during fungal infection [46]. Here, CD40LG is linked to fungal infectious disease.