LTβR-Ig treatment resulted in mice unable to control systemic parasitaemia as efficiently as mice treated with an irrelevant antibody or untreated mice (S7A Fig and S34 Data), and in a worsening in the clinical scoring (S7B Fig and S35 Data), mirroring previous work using Ltb-/- mice infected with T. brucei in the context of intradermal infections [76]. Here, LTB is linked to infection.