CR2 and infection: Cells within clusters 3, 5, and 6 up-regulated genes associated with BRCs [58] during infection, including Cxcl13 (Cluster 5), Itga7, Ltbr (cluster 5 and 6), Madcam1 (cluster 5), Cr2 (cluster 3 and 6), and Tnfsf11 (encoding for RANKL) in cluster 3 (Figs 3C and S3B).