IL33 and infection: While animals with intact ST2 signaling on microglia survived at rates comparable to WT animals, Cx3cr1ERT2Cre/+:: Il1rl1fl/fl mice displayed significantly increased mortality (Fig 4F) and weight loss (S4H Fig), comparable to that observed when this infection model was applied to mice globally lacking ST2 or IL-33 (Fig 1A). A recent study identified ST2 expression on peripheral sensory neurons in the context of sterile skin injury [45].