Given the loss of MBP+IL-33+ oligodendrocytes in regions of known synaptic stripping as well as previous studies that have shown oligodendrocyte cell death upon flavivirus infection in vitro and in vivo[25–27], we hypothesized that oligodendrocytes represented a probable source of released IL-33 following neuroinvasive WNV infection. The gene discussed is IL33; the disease is Flavivirus Infections.