ESR1 and neoplasm: A limitation of the published models is that they include postoperative variables from surgical specimens, including pathological tumor size [10,14], estrogen receptor (ER) status [5,7,13,16], progesterone receptor (PR) status [5,7], human epidermal growth factor receptor 2 (HER2) status [5,7,10,16], proliferation index Ki67 value [5,7,13], Nottingham histological grade (NHG) [5,7,8,12], histological type [5,7,8,12], and lymphovascular invasion (LVI) [6,7,11].