In contrast with these results, Cagatay and Ozturk (2002) reported that in hepatocellular carcinoma cells, mut-p53 increases β-catenin levels, possibly through regulation of Siah1 (Seven in absentia homolog 1), a target of wt-p53 that participates in β-catenin degradation. The gene discussed is SIAH1; the disease is hepatocellular carcinoma.