In this regard, it has been demonstrated in HCT116 colon cancer cells and in intestinal organoid cultures that phosphorylation of β-catenin at Ser 552 by AKT contributes to β-catenin stability and enhances its transcriptional activity (Behrouj et al. 2021; Wang et al. 2020; Fang et al. 2007). The gene discussed is AKT1; the disease is colonic neoplasm.