TP53 and colorectal cancer: Comparing the expression of c-Myc, a target gene of the canonical Wnt pathway, in wtp53 versus mut-p53 colorectal samples, it was clearly shown that those patients with altered p53 display higher levels of c-Myc expression (Fig. 1D), which was also observed in the TCGA Pancancer database, in which a higher expression of c-Myc was also found in colorectal cancer patients expressing mut-p53 compared to wt-p53 expression (Fig. 1E).