Overall, considering the available evidence, treatment with potent 5-HT2A antagonists, including medicines, is anticipated to diminish the effects of psychedelics (e.g. antipsychotics risperidone, olanzapine and pipamperone, antidepressants mirtazapine, mianserin and etoperidone as well as migraine prevention drug pizotifen). The gene discussed is HTR2A; the disease is migraine disorder.