Duchenne and Becker muscular dystrophy due to variants in dystrophin were also explored as an edge case as complex rearrangements in the gene are often encountered.26 Approximately 60% of pathogenic dystrophin variants are large insertions or deletions that lead to frameshift errors downstream, whereas approximately 40% are substitutions or small insertions and deletions. Here, DMD is linked to Duchenne and Becker muscular dystrophy.