Cross-cutting inheritance qualifiers generated for use with inheritance terms above were expanded by consideration of edge cases such as craniofrontonasal dysplasia due to EFNB1, which requires heterozygosity.24 Qualifier terms were refined to be compatible with all inheritance and allelic requirement terms by iterative discussion, to enable recording of data important to reproductive advice and family screening. Here, EFNB1 is linked to Craniofrontonasal dysplasia.