MALAT1 and nervous system disorder: HCN channel plasticity has been observed in several neurological disorders including chronic stress and depression,12, 51, 203, 226, 227, 228, 229 epilepsy,6, 8, 9, 11, 52, 57, 60, 189, 198, 200, 201, 202, 204, 230, 231, 232, 233, 234, 235 Alzheimer's disease,9, 236, 237 and Fragile X syndrome.199, 238, 239, 240, 241