Cianciaruso et al. [85] demonstrated that cyclooxygenase-1 (COX1) and thromboxane A synthetase 1 (TBXAS1), which participate in the arachidonic acid pathway, were enriched in TAMs-derived exosomes, but were sparse in the vesicles of MC38 colorectal cancer. This evidence concerns the gene PTGS1 and colorectal cancer.