Gabrusiewicz et al. [53] reported that monocytes can preferentially and rapidly absorb glioblastoma stem cell-derived exosomes, releasing multiple factors, particularly STAT3—a key molecular hub for tumor-mediated immunosuppression—thereby promoting the expression of programmed death ligand 1 (PD-L1) and polarization into the M2 phenotype. The gene discussed is STAT3; the disease is neoplasm.