In 28 IR MB-NHL patients, the most commonly mutated genes were TP53 (54%, 15/28), ID3 (50%, 14/28), CCND3 (36%, 10/28), DDX3X (25%, 7/28), MYC (25%, 7/28), and GNA13 (18%, 5/28). The gene discussed is DDX3X; the disease is non-Hodgkin lymphoma.