It is a histidine rich protein 2 (HRP2)-based test that has more than tenfold lower limit of detection (10–40 pg/ ml of HRP2) when compared to the conventional SD Bioline Malaria Ag P.f RDT (800–1000 pg/ml of HRP2), and was prequalified by the WHO in 2019 [29]. The gene discussed is HDGFL2; the disease is malaria.