Insufficient angiogenesis can hinder the restoration following ischemia and may lead to heart failure post MI.249 Regardless of whether under normoxic or hypoxic conditions, the chaperone function of heat shock protein 90 (Hsp90) can protect its target proteins, including HIF-1α, from degradation.250 Acetylation of Hsp90 leads to its dissociation from the target proteins, facilitating their degradation. The gene discussed is HIF1A; the disease is heart failure.