Notably, anti-transferrin antibody, transferrin knockdown, and peptide interference treatment almost completely suppressed hypothermia- and hypoxia-induced hypercoagulability.155 Furthermore, HIF-2α may serve as a beneficial short-term adaptation mechanism at high altitudes, but excessive activation of HIF-2α can lead to chronic mountain sickness, which can be fatal and impede reproductive capabilities. This evidence concerns the gene EPAS1 and chronic mountain sickness.