Additionally, there is a notable reduction in renal function.348 While the precise mechanistic regulation of the transition from glucose to fat metabolism during hibernation remains incompletely understood, it appears to share similarities with the mechanisms observed in instances of starvation, diabetes, and caloric restriction.349–352 And HIF-1α expression during hibernation may vary across tissues and is potentially linked to species-specific differences in gene expression patterns, which needs deeper investigations. Here, HIF1A is linked to diabetes mellitus.