HIF1A and myocardial infarction: The reversible acetylation of both histone and non-histone proteins at lysine residues is controlled by histone deacetylases (HDACs) and histone acetyltransferases (HATs).244,245 Apart from hydroxylation modifications, HIF-1α can undergo reversible lysine acetylation as a post-translational modification.246–248 Acetylation modification of HIF-1α enhances its interaction with von Hippel-Lindau protein (pVHL), facilitating the degradation of HIF-1α.246 Angiogenesis is crucial for the recovery of cardiac and circulatory system function after MI.