KCNA10 and cancer: Advanced chetomin analogs like ETP2 and ETP3 show reduced toxicity to normal cells compared to natural chetomin.549,550 Another inhibitor of the Eck’s group, arylsulfonamide KCN1, was identified in vitro through a surface plasmon resonance (SPR) assay.551 In vitro, KCN1 hampers pancreatic cancer cell growth and triggers cell cycle arrest in a dose-dependent manner, with good pharmacological properties.552,553 Chetomin derivatives and KCNs are able to minimize in vivo toxicity, suggesting their potential for treating conditions with HIF overexpression, like vascular diseases and cancers.