EP300 and neoplasm: Furthermore, researchers have crafted peptoid inhibitors to selectively target the binding of HIF-1α with p300 by mimicking energetically important protein residues, such as Leu818, Leu822, Asp823, and Gln824.554 Through structure-activity relationship (SAR) analysis, a designed peptidomimetic HBS1 effectively inhibited tumor growth in an renal cell carcinoma (RCC) xenograft mouse model.554 Computational and structural analyses have identified the CH1 domain of p300/CBP interacting with HIF-1α helix residues.