Ischemic heart disease is caused by coronary artery stenosis or plaque rupture, resulting in reduced myocardial blood flow or oxygen supply.67 In 2000, researchers discovered that during the early stages (within the first 24 h) following acute myocardial infarction (MI) or during acute myocardial ischemia, HIF-1α significantly increases in the peri-infarct region of the ischemic hearts, while it remains undetectable in non-ischemic or non-infarcted tissue specimens.68 This suggests that HIF-1α may serve as an early molecular marker for myocardial ischemia or infarction. The gene discussed is HIF1A; the disease is myocardial ischemia.