Overexpression of SMPD3 lentivirus and administration of ceramide counteract the benefits of adipocyte HIF-1α deficiency in atherosclerosis.460 Type 2-neutral sphingomyelinase (nSMase2), also known as SMPD3, is situated within membrane structures through the insertion of palmitoylated residues into the lipid bilayer and its interaction with anionic phospholipids. This evidence concerns the gene SMPD3 and atherosclerosis.