This marks the era of a metabolic perspective in the comprehension of HIF-1’s regulation of the hypoxic response.26 The interconnection between the HIF-related hypoxic signaling pathway and glycolysis metabolism was later regarded as fundamental in establishing the pivotal role of HIFs in both cardiac and tumor metabolic pathways.6,27 The spatial structure of the HIF-1 protein was extensively investigated, leading to the first isolation, purification, and characterization of HIF-1 in early 1995. The gene discussed is HIF1A; the disease is neoplasm.