AGT and hypertensive disorder: Among the pathways involved in the development of hypertension, the renin–angiotensin system (RAS) plays a crucial role; particularly, the angiotensin II (Ang II)–Ang II type 1 receptor (AT1R) signaling pathway directly affects the arterial constriction (2), tubular sodium reabsorption (3, 4, 5), the release of aldosterone, a mineralocorticoid (6, 7), and the induction of insulin resistance (8).