As previously reported (40), the analysis of transcriptomic database (TNMplot) showed that CYP27A1 is expressed in breast cancer in paired tumors (n = 7569), adjacent normal breast tissues (n = 252) and metastasis (n = 82), showing a slight decrease between normal and cancer tissues (median fold change tumor/normal = 0.87; median fold change metastatic/tumor = 0.98) (Fig. 3B). Here, CYP27A1 is linked to cancer.