In rare familial AD cases, genetic predisposition due to mutations in the amyloid precursor protein (APP) accounts for abundant and early presence of Aβ pathology and accelerated disease progression [3], whereas in the more prevalent sporadic variant, environmental and ‘lifestyle’ factors, like stress or diet, are regarded as important players in disease pathogenesis, next to agingargethispage3pt per se [4, 5]. The gene discussed is APP; the disease is Alzheimer disease.