TP53 and hepatocellular carcinoma: NR group enrichment was significantly lower in several previously identified molecular classifications of HCC, including the EpCAM (p = 8 × 10−6), HC1 TIGER (p = 0.05), G3 Boyault (p = 0.0057), and Chiang proliferation (p = 2.8 × 10−8) classes (Figure 6A; Table S6).23–26 Assessing relationships to driver mutations, NR group enrichment was significantly lower in TP53 mutant tumors (p = 0.0062) but trended higher in CTNNB1 mutant tumors (p = 0.071, Figures S9A and S9B; Table S6).