HSPG2 and hepatocellular carcinoma: Moreover, rare mixed tumors develop that contain both HCC- and iCCA-like malignant cells.28 Recent evidence has suggested that progenitor liver cells can give rise to both HCC and iCCA and even hepatocytes are able to transdifferentiate into cholangiocyte-like cells responsible for iCCA formation.4 Knowing what TFs are needed to maintain hepatocytic or cholangiocytic functions in PLC may help us exploit transcriptional networks that drive tumors into a more differentiated state.