SERPINB3 transcript levels were upregulated in tumor tissues compared with nontumor tissues, and the upregulation of SERPINB3 in PDAC was associated with decreased patient survival in both the NCI-UMD-German cohort and a validation cohort (Moffitt cohort4) (Figures 1B and 1C). This evidence concerns the gene SERPINB3 and neoplasm.