PECAM1 and neoplasm: Furthermore, IHC of the endothelial marker CD31 and the reactive oxygen species (ROS) marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) revealed that angiogenesis and oxidative stress are upregulated in the tumor xenografts of SERPINB3-overexpressing AsPC-1 in the orthotopic model (Figures 3G and 3H).