CD28 and cancer: Figure 5C, D shows the enrichment and grading results of GSEA, indicating that CD72 is closely associated with signaling pathways such as the Pd 1 signaling pathway, the CTLA4 pathway, the Th17 cell differentiation pathway, the B-cell receptor signaling pathway, costimulation of the CD28 family, primary immune deficiencies, cancer immunotherapies via Pd1 blockade, regulators of TCR signaling, and T-cell activation, as well as other genes associated with tumorigenesis, invasion, and angiogenesis.