Based on GSEA enrichment analysis, CD72 and its co-expressed mRNAs are enriched in signaling pathways such as Pd 1 Signaling, CTLA4 Pathway, Th17 Cell Differentiation Pathway, B Cell Receptor Signaling Pathway, Costimulation By the CD28 Family, Primary Immunodeficiency, Cancer Immunotherapy By Pd1 Blockade, Modulators of Tcr Signaling and T Cell Activation, Costimulation By the CD28 Family, Primary Immunodeficiency, Cancer Immunotherapy By Pd1 Blockade, Modulators of Tcr Signaling and T Cell Activation, and other Signaling Pathways associated with tumor immunity and tumorigenesis. This evidence concerns the gene CD28 and neoplasm.