In addition, CD72 was associated with poor patient prognosis and could be an independent prognostic factor for KIRC.CD72 may promote tumor development by regulating the cell cycle and immune-related signaling pathways and facilitating immune cell infiltration.CD72 also showed a significant positive correlation with PD-L1 (CD274), CTLA4, and PD-1 (PDCD1) immunotherapeutic targets. Here, CD72 is linked to neoplasm.