What’s more, the correlation analysis and GSEA results in other cancers where RPLP2 was significantly upregulated indicated that PRLP2 may play an important role in inhibiting ferroptosis of cancer cells through GPX4 in GBM, LGG, PAAD, TGCT and especially THYM, and further experimental verification was needed. This evidence concerns the gene RPLP2 and glioblastoma.