IREB2 and hepatocellular carcinoma: In addition, the correlation analysis between RPLP2 and key ferroptosis gene regulators in TCGA HCC samples from FerrDb showed that RPLP2 positively correlated with ferroptosis suppressor gene GPX4, and negatively associated with ferroptosis driver genes IREB2, BECN1 and NCOA4 (Fig. 8B).