CDON and congenital heart disease: The deletion of 11q24.1q24.3 detected in another fetus (case 6 in Table 2) spans approximately 9.5 Mb (chr11: 121,235,870–130,733,365), including a large number of OMIM genes such as DCPS, CDON, FLI1, etc. The deletion of this genetic segment may lead to multiple organ abnormalities, such as brain malformation, kidney dysplasia, congenital heart disease and so on.