The results showed that compared to the sh-NC group, the lactate and ATP contents in tumor tissues were significantly reduced in the sh-LHX9 group (Fig. 6D, E), and the mRNA and protein expression of glycolysis-related genes (GLUT1, HK2, LDHA, and PDK1) were also significantly reduced (Fig. 6F). Here, HK2 is linked to neoplasm.