NFKB1 and neoplasm: Our findings revealed significant enrichment of PI3K_AKT_MTOR_SIGNALING, MTORC1_SIGNALING, and TNFA_SIGNALING_VIA_NFKB in tumor cells compared to normal cells, suggesting a potential mechanism by which tumors protect themselves and enhance survival by suppressing these processes (Supplementary Fig. 2A,B).