To investigate whether ZHX2 is associated with susceptibility to liver toxicity and mitochondrial dysfunction in human, expression of ZHX2 and TOM20, a widely used mitochondrial mass marker, were examined by multiplexed immunofluorescence staining in liver biopsies from DILI patients, normal non-tumor sections from patients with hepatic hemangioma as normal control (Fig. 8a and Supplementary Table 1). The gene discussed is ZHX2; the disease is Hepatic hemangioma.