To investigate whether ZHX2 is associated with susceptibility to liver toxicity and mitochondrial dysfunction in human, expression of ZHX2 and TOM20, a widely used mitochondrial mass marker, were examined by multiplexed immunofluorescence staining in liver biopsies from DILI patients, normal non-tumor sections from patients with hepatic hemangioma as normal control (Fig. 8a and Supplementary Table 1). This evidence concerns the gene TOMM20 and Hepatic hemangioma.