ROCK2 and Hepatic fibrosis: Notably, by normalizing the HYP data to week 6 (start of treatment) we found that the highest dose of GV101 (150 mg/kg) reduced collagen to levels observed in livers of normal water drinking mice suggesting that the highly selective ROCK2 inhibitor not only blocks the progression but reverses the established TAA-induced liver fibrosis in mice (Supplementary Fig. 1c).