Notably, among published PD and AD risk genes (Supplementary Data 2), we found four PD risk genes (SH3GL2, LRRK2, SATB1, BST1)29,30, and an Alzheimer’s disease risk gene (CR1)31, which were highly expressed in these vulnerable DaNs subclusters (Supplementary Fig. 8d). The gene discussed is SATB1; the disease is Alzheimer disease.