We knocked down OLIG2 with specific targeting short hairpin RNAs (shRNAs) or siRNAs in patient-derived GSCs and glioma cells respectively, then found that INHEG expression was decreased upon OLIG2 downregulation as measured by qRT-PCR and western blotting (Fig. 3g and Supplementary Fig. 3c). This evidence concerns the gene OLIG2 and central nervous system cancer.