NOP58 and neoplasm: By in silico analysis of Histone 3 lysine 27 acetyl chromatin immunoprecipitation followed by deep sequencing (H3K27ac ChIP-seq) data from matched stem-like tumor-propagating cells (TPCs) and DGCs23, the C/D box snoRNP protein components (FBL, NOP56, NOP58 and NHP2L1) displayed enhanced H3K27ac signal in TPCs (Fig. 1f).